Protective Potential of Lycopene Enriched Tomato Extract against Dexamethasone Induced Hepatic and Renal Damage in Mice


 Aim: The present study was carried out to determine the protective potential of Lycopene enriched tomato extract (LycT) against hepatic and renal damage caused in mice by dexamethasone administration.
 Study Design: Male LACA were randomly divided into four treatment groups (n=6-7 animals per group) depending upon they received. Group I (control) served as control orally administered with olive oil (vehicle) thrice a week for five weeks. II (DEX) intraperitoneallly (i.p.) at dose 5 mg/kg b.w. on alternate days three III (p.o.) LycT IV (LycT+DEX) co-administered according above mentioned regimen
 Results: Dexamethasone evident from disturbed histoarchitecture, deranged levels organ function markers (alkaline phosphatase, serum glutamate oxaloacetate transaminase, pyruvate total direct bilirubin, urea, creatinine) enhanced level cell (lactate dehydrogenase) oxidative stress (lipid peroxidation) markers. Increased blood glucose level, decreased glycogen along inhibited activities enzymes involved glycolysis (hexokinase, phosphoglucoisomerase) indicated altered metabolism DEX group. mitigation histoarchitectural alterations, markers, improved ramped up antioxidant defense system induced ill effects.
 Conclusions: These results point towards beneficial effects tissues mice.